Folate Receptor Near-Infrared Optical Imaging Provides Sensitive and Specific Intraoperative Visualization of Nonfunctional Pituitary Adenomas
نویسندگان
چکیده
منابع مشابه
Increase in folate receptor alpha expression in nonfunctional pituitary adenomas.
AIM Human pituitary adenomas account for 10% of intracranial tumours and occur in about 20% of the population. They cause hypopituitarism or the compression of adjacent regional structures. However, little is known about the molecular pathogenesis that contributes to the development of these tumours. MATERIAL AND METHODS In this study, we investigated the relationship between the expression l...
متن کاملIn vivo assay of folate receptors in nonfunctional pituitary adenomas with 99mTc-folate SPECT/CT.
UNLABELLED The objective of this study was to evaluate the in vivo assay of folate receptors in nonfunctional pituitary adenomas using preoperative (99m)Tc-folate SPECT/CT and Western blot analysis (WBA) of surgical specimens as the standard. METHODS Fifty-six patients (29 men, 27 women; age range, 29-82 y) with clinically nonfunctional pituitary adenomas on MRI underwent preoperative imaging...
متن کاملA folate receptor-specific activatable probe for near-infrared fluorescence imaging of ovarian cancer.
We have developed a folate receptor-specific activatable probe for in vivo near-infrared fluorescence imaging of ovarian cancer. This probe becomes highly fluorescent only when its linker is cleaved by a tumor-associated lysosomal enzyme cathepsin B after internalization into folate receptor-positive cancer cells.
متن کاملDifferential expression of folate receptor in pituitary adenomas.
Pituitary adenomas cause significant morbidity caused by compression of regional structures or the inappropriate expression of pituitary hormones. However, little is known about the molecular changes that contribute to the development of these tumors. To investigate these changes, we recently used cDNA microarray analysis to identify several genes with altered expression patterns in pituitary a...
متن کاملIntraoperative near-infrared fluorescence imaging of parathyroid adenomas with use of low-dose methylene blue.
BACKGROUND Intraoperative identification of parathyroid adenomas can be challenging. We hypothesized that low-doses methylene blue (MB) and near-infrared fluorescence (NIRF) imaging could be used to identify parathyroid adenomas intraoperatively. METHODS MB was injected intravenously after exploration at a dose of 0.5 mg/kg into 12 patients who underwent parathyroid surgery. NIRF imaging was ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Operative Neurosurgery
سال: 2018
ISSN: 2332-4252,2332-4260
DOI: 10.1093/ons/opy034